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History of Cryolipolysis

in 1970 when researchers discovered that some children developed dimples due to sucking on ice lollies.1 The idea that cold can selectively affect fat inspired Harvard scientists Dieter Manstein and R. Rox Anderson to develop the proven Cryolipolysis® science on which CoolSculpting® technology is based.*2 The patented Cryolipolysis® technology is exclusively licensed by Allergan®.3-6

*Data obtained from cryolipolysis investigations using a pig model.

What Evidence Supports CoolSculpting®

What evidence supports CoolSculpting®

peer-reviewed publications on CoolSculpting®
as of February 20181


CoolSculpting® uses a non-surgical procedure called cryolipolysis to reduce subcutaneous fat.2 CoolSculpting® targets and cools fat cells to temperatures that trigger fat cell apoptosis.3The body’s immune system then naturally processes the apoptotic cells, which are removed through an inflammatory process.1

*Data obtained from cryolipolysis investigations using a pig model.

How CoolSculpting® works

CoolSculpting® reduces stubborn fat through Cryolipolysis®

How It Works 1

The CoolSculpting® procedure targets and cools fat cells to temperatures that trigger fat cell apoptosis*1

How It Works 2

CoolSculpting® selectively damages subcutaneous fatty tissue while preserving the skin and surrounding tissues*1

How It Works 3

Following treatment, fat cells enter apoptosis and the body’s immune system naturally processes the fat and removes dead cells2

How It Works 4

CoolSculpting® has demonstrated fat layer reductions across multiple treatment areas of up to 27% at 6 months3

Images are for illustrative purposes only.

*Data obtained from cryolipolysis investigations using a pig model.

Study conducted July 2009 – January 2011 on a total of 112 patients, with n=85 patients available for follow-up caliper evaluations.
The average fat reduction at follow-up was 21.5%. The 27% reduction refers specifically to the lower abdomen (n=55).
Average reductions in other treatment areas included: brassiere rolls 20% (n=4), lumbar rolls 22% (n=2), hip rolls 25% (n=20), inner thighs 17% (n=3), and medial knees 18% (n=1).
Patients were treated at one or more sites for a total of up to four treatment areas in a single session.

Why is CoolSculpting® successful?
Because it works.

Our Research and Development refines the science behind CoolSculpting®:

The proposed mechanism of cryolipolysis includes intracellular lipid crystallization that contributes to the delayed apoptosis. Lipids in the liquid state are not birefringent while solid lipid crystals exhibit strong birefringence, which is detectable under polarized microscopy.4

Temp –7.7 ⁰C Ramp Flow 2 Rate 6 ⁰C/min Limit –15 ⁰C
Temp –14.7 ⁰C Ramp Flow 2 Rate 6 ⁰C/min Limit –15 ⁰C

Visualisation of lipid crystallisation within human fat cells using cross-polarized microscopy with a cryostage.4

Images courtesy of Allergan


Why is CoolSculpting® different?

FreezeDetect® technology

CoolSculpting® is a non-invasive fat reduction treatment,1 using cold-assisted lipolysis with patented FreezeDetect® technology that may prevent patient burns.2


Approximate percentage of people surveyed who feel they have excess fat in areas shown:*1

*Market research was undertaken in 2016/17 by online survey format across 27 international countries, N=280,199 screener size, N=32,570 passed screening criteria (aged 18–75 years, BMI 18.5–34.9, income criteria [set per country] and aesthetically oriented: agreed to ‘I feel I have excess fat on parts of my body/face’ and ‘I care about improving my appearance’, and must have either used or would consider using a fat reduction/body contouring procedure.1